ROTA RODAPPARATUS TWO COMPARTMENT
ROTA ROD is the instrument meant forstudying the effect of diazepamâs on the muscle grip strength of mice.
A versatile built with LSI chips isequipped with Four/ Two/Three compartments and Four/Two/Three independent 4digits. Digital milliseconds timer for measuring the fall-off time of the mice.
It is also equipped with a motorcoupled with rotating rod whose speed can be varied with the help of the frontpanel knob marked with an arrow or speed less than 10 RPM.
One of the important pharmacologicalactions of ant anxiety of agents of class of drugs is muscle relaxing property.The skeletal muscle relaxation together with taming or calming effect theseagents reduces anxiety and tension. The loss of muscle-grip is an indication ofmuscle relaxation, this can be easily checked in animals, usingROTAROD.
The difference in the fall of timefrom the rotating rod between the control and diazepamâs treated animals istaken an index of muscle relaxation. The rate of rotation of the rod should beadjusted such that normal mouse can stay on the rod for an appropriate periodof time.