ROTAROD APPARATUS 4 COMP. DIGI. RPM
ROTAROD is the instrument meant for studying the effect of on the muscle gripstrength of mice.
A versatile built with LSI chips isequipped with Four/ Two/Three compartments and Four/Two/Three independent 4digits. Digital milliseconds timer for measuring the fall-off time of the mice.
It is also equipped with a motorcoupled with rotating rod whose speed can be varied with the help of the frontpanel knob marked with an arrow or speed less than 10 RPM.
One of the important pharmacologicalactions of anti anxiety of agents of class of drugs is muscle relaxingproperty. The skeletal muscle relaxation together with taming or calming effectthese agents reduces anxiety and tension. The loss of muscle-grip is anindication of muscle relaxation; this can be easily checked in animals, usingROTAROD.
The difference in the fall of timefrom the rotating rod between the control and treated animals is taken an indexof muscle relaxation. The rate of rotation of the rod should be adjusted suchthat normal mouse can stay on the rod for an appropriate period of time.
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